HOPE study: How can the outcomes of oPEn tibia fractures be improved in a low income country
| dc.contributor.author | Schade, Alexander Thomas | |
| dc.date.accessioned | 2021-11-25T17:08:14Z | |
| dc.date.available | 2021-11-25T17:08:14Z | |
| dc.date.issued | 2021-01-13 | |
| dc.description.sponsorship | Type of research study: A prospective observational cohort study that will investigate patient reported outcomes 6 months after injury. It will also include a national training course on open fracture management for Orthopaedic Clinical Officers. Background: Road traffic injury (RTI) is the largest cause of death amongst 15-25-year olds worldwide and disability from open tibia fractures in survivors is rapidly increasing in LMICs. In high-income countries, open tibia fractures have devastating consequences, including a 10% amputation rate, 28% infection rate and only 20% of patients with open tibia fractures return to work at 1 year. As the typical presentation and impact of this injury in LMICs is unknown, urgent research in this area has been prioritised globally. Our study will be a multi-centre prospective observational cohort study that will investigate disability and economic outcomes of people with open tibia fractures in Malawi. Type of research study: A prospective observational cohort study that will investigate patient reported outcomes 6 months after injury. It will also include a national training course on open fracture management for Orthopaedic Clinical Officers. Problem: The impact of open tibia fractures on patients and how these injuries are treated in Malawi remains unknown. This information is therefore urgently needed to inform clinicians and policy makers about the best care for people suffering open tibia fractures in Malawi. Objectives: This project aims to collect patient reported outcomes that will describe the function, quality of life and economic burden of open tibia fractures over the six months following injury in selected district and central hospitals in Malawi. Methods: A prospective cohort study which will recruit participants with open tibia fractures presenting to two central and three district hospitals over the one-year period. The central hospitals are Queen Elizabeth Central Hospital (QECH) and Kamuzu Central Hospital (KCH); the three district hospitals are NchteuNtcheu, Dedza and BalakaMachinga District Hospitals. Three research assistants will be trained to collect high quality data using a standard questionnaire on tablets. The data collected will include demographic details, mechanism of injury, diagnosis, treatment details and disposition. We will administer patient reported outcomes including the Chichewa EQ-5D, SMFA and a modified version of the WHO TB economic costing tool at six weeks, three months and six months post injury. Linear regression analysis will be used to model and investigate associations between fracture severity and key study outcomes (adjusted for confounders including age and gender). The study will not collect any names and patients will be fully anonymised. Expected Findings and Dissemination: Results of this descriptive study will be used to investigate different treatment options for open tibia fractures appropriate for Malawi and similar settings. The findings of this study will also be compiled into a written report which will be made available to each participating district hospital and COMREC. In addition, a copy of the report will be made available to the Ministry of Health headquarters as the findings may have an impact in future planning and policies in terms of resource allocation and formulation of intervention strategies. An abstract may be presented to national and international conferences and one or more articles may be submitted to a peer reviewed journal for publication. | en_US |
| dc.identifier.uri | http://rscarchive.kuhes.ac.mw/handle/20.500.12988/534 | |
| dc.language.iso | en | en_US |
| dc.publisher | Kamuzu University of Health Sciences | en_US |
| dc.relation.ispartofseries | Ethics Protocol;P.09/20/3130 | |
| dc.title | HOPE study: How can the outcomes of oPEn tibia fractures be improved in a low income country | en_US |
| dc.type | Plan or blueprint | en_US |